The Church of the Annunciation of the Virgin Mary in Mesa Lassithi is a traditional Orthodox Christian church dedicated to the Annunciation to the Virgin Mary, a key event in Christian belief when the Archangel Gabriel announced to Mary that she would give birth to Jesus Christ.

The church serves as a place of spiritual worship for locals and visitors alike, embodying the faith and religious traditions of the area. It is part of the rich tapestry of Annunciation churches across Crete, offering a tranquil and reflective environment in the peaceful village setting of the Lassithi Plateau.